Leaves, which show antileukemic activity, contain a-amyrin, b-sitosterol, stigmasterol, and campesterol, 7-keto-b-sitosterol, stigmast-5-ene-3-b, 7-a-diol, and stigmast-5-ene-3 b, 7 b-diol (Morton, 1981). Leaves contain isovitexin and vitexin. From the drug (nut?) saccharose, raffinose, stachyose, glucose, fructose, galactose, protein, and an oil, largely of oleic- and linoleic-acids (List and Horhammer, 1969–1979), curcasin, arachidic-, linoleic-, myristic-, oleic-, palmitic-, and stearic-acids are also reported (Perry, 1980).

 

The poisoning is irritant, with acute abdominal pain and nausea about 1/2 hour following ingestion. Diarrhea and nausea continue but are not usually serious. Depression and collapse may occur, especially in children. Two seeds are strong purgative. Four to five seed are said to have caused death, but the roasted seed is said to be nearly innocuous. Bark, fruit, leaf, root, and wood are all reported to contain HCN (Watt and Breyer-Brandwijk, 1962). Seeds contain the dangerous toxalbumin curcin, rendering them potentially fatally toxic

 

 

According to Hartwell, the extracts are used in folk remedies for cancer. Reported to be abortifacient, anodyne, antiseptic, cicatrizant, depurative, diuretic, emetic, hemostat, lactagogue, narcotic, purgative, rubefacient, styptic, vermifuge, and vulnerary, physic nut is a folk remedy for alopecia, anasorca, ascites, burns, carbuncles, convulsions, cough, dermatitis, diarrhea, dropsy, dysentery, dyspepsia, eczema, erysipelas, fever, gonorrhea, hernia, incontinence, inflammation, jaundice, neuralgia, paralysis, parturition, pleurisy, pneumonia, rash, rheumatism, scabies, sciatica, sores, stomachache, syphilis, tetanus, thrush, tumors, ulcers, uterosis, whitlows, yaws, and yellow fever (Duke and Wain, 1981; List and Horhammer, 1969–1979). Latex applied topically to bee and wasp stings (Watt and Breyer-Brandwijk, 1962). Mauritians massage ascitic limbs with the oil. Cameroon natives apply the leaf decoction in arthritis (Watt and Breyer-Brandwijk, 1962).

Colombians drink the leaf decoction for venereal disease (Morton, 1981). Bahamans drink the decoction for heartburn. Costa Ricans poultice leaves onto erysipelas and splenosis. Guatemalans place heated leaves on the breast as a lactagogue. Cubans apply the latex to toothache. Colombians and Costa Ricans apply the latex to burns, hemorrhoids, ringworm, and ulcers. Barbadians use the leaf tea for marasmus, Panamanians for jaundice. Venezuelans take the root decoction for dysentery (Morton, 1981). Seeds are used also for dropsy, gout, paralysis, and skin ailments (Watt and Breyer-Brandwijk, 1962). Leaves are regarded as antiparasitic, applied to scabies; rubefacient for paralysis, rheumatism; also applied to hard tumors (Hartwell, 1967–1971). Latex used to dress sores and ulcers and inflamed tongues (Perry, 1980). Seed is viewed as aperient; the seed oil emetic, laxative, purgative, for skin ailments. Root is used in decoction as a mouthwash for bleeding gums and toothache. Otherwise used for eczema, ringworm, and scabies (Perry, 1980; Duke and Ayensu, 1984). We received a letter from the Medicial Research Center of the University of the West Indies shortly after the death of Jamacian singer Robert Morley, "I just want you to know that this is not because of Bob Morley's illness, why I am revealing this ... my dream was: this old lady came to me in my sleep with a dish in her hands; she handed the dish to me filled with some nuts. I said to her, "What were those?" She did not answer. I said to her, "PHYSIC NUTS." She said to me, "This is the cure for cancer." We found this Jamaican dream rather interesting. Four antitumor compounds, including jatropham and jatrophone, are reported from other species of Jatropha (Duke and Ayensu, 1984). Homeopathically used for cold sweats, colic, collapse, cramps, cyanosis, diarrhea, leg cramps.